Endocrine Abstracts

Introduction: In metformin-associated lactic acidosis with renal dysfunction inhibition of hepatic gluconeogenesis by drug accumulation may aggravate fasting induced-ketoacidosis. We report the occurrence of metformin-associated lactic acidosis with concurrent euglycemic ketoacidosis in three patients with renal failure.Cases: The first patient was a 79-year-old woman who suffered from chronic kidney disease stage IIIa after traumatic uninephrectomy, and...

Background: Hashimoto’s thyroiditis (HT), the most prevalent autoimmune disorder of the thyroid (AITD) is characterized by the presence of circulating autoantibodies, induced by a not fully understood dysregulation of the immune system. MicroRNAs (miRNAs) are small noncoding RNAs, which can play a pivotal role in immune functions and the development of autoimmunity. The aim of the present investigation was to evaluate whether a panel of nine selected miRNAs differs in ser...

Context: The aldosterone to active renin ratio (AARR) is the recommended screening test for primary aldosteronism (PA), but prospective study data on its sensitivity and specificity are sparse.Objective: We investigated the diagnostic accuracy of the AARR for detecting PA.Design: This is a prospective diagnostic accuracy study.Setting: This study was conducted from February 2009 to August 2015 at the outpatie...

Introduction: Soluble ST2 (sST2) is the truncated soluble form of the ST2 receptor in the circulation. It is a decoy receptor of IL-33 and thereby inhibits the effects of IL-33/ST2 signaling. Elevated levels of sST2 have been associated with various adverse cardiovascular outcomes. Recently, potential associations of sST2 with obesity and type 2 diabetes mellitus (T2DM) have been described in the general population. In this study, we determined possible cross-sectional associa...